Fig. 1.

Autoradiographic distribution of¹²⁵I-α-CtxMII binding in control monkey brain. Expression is observed predominantly in the nigrostriatal and visual systems, as illustrated by representative sections throughout the brain (14.0 mm anterior to the interaural line, A14.0; 12.0 mm, A12.0; 5.0 mm, A5.0; and 2.0 mm, A2.0). Nonspecific¹²⁵I-α-CtxMII (CTX-NS) binding using 0.1 μm epibatidine is depicted in the set of brain sections at the left, total ¹²⁵I-α-CtxMII (CTX-Total) binding is in thecenter, and dopamine transporter (DAT) binding ([¹²⁵I]RTI-121) is at the right.Cd, Caudate; Cx, cortex;LG, lateral geniculate nucleus; IP, interpeduncular nucleus; MH, medial habenula;NA, nucleus accumbens; OT, olfactory tubercle; Put, putamen; SN, substantia nigra; SC, superior colliculus; SOD, supraoptic decussation; VTA, ventral tegmental area. Scale bar, 1.0 cm.