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Exercise and IGF-I increase brain glucose uptake in brain-damaged animals. Domoic acid-lesioned mice (b) show increased glucose uptake in the hippocampus compared with nonlesioned mice (a). Glucose uptake is further increased by either exercise (d) or IGF-I (c) not only in the hippocampus but also in other telencephalic areas. Representative brain autoradiography hemisections are shown.CA2, CA3, Hippocampal pyramidal cell layers; DG, hippocampal dentate gyrus; V, ventral; D, dorsal.
