Fig. 8.
I4-AP is critical for the production of high-frequency subthreshold membrane oscillations.Aa, Ab, 4-AP (10 μm) transformed the high-frequency subthreshold oscillations into low-frequency oscillations. Ac, FFT analysis showed the dominant frequency of subthreshold oscillation shifted from ∼90 to ∼10 Hz after 4-AP application. Ba, Bb, Effects of 10 mm TEA on subthreshold oscillations. Compared with 4-AP, TEA effects were modest. C, Cd2+ (100 μm) had minimal effects on both frequency and amplitude of subthreshold oscillations.