Fig. 8.

The effect of acute NMDA receptor blockade by MK-801 on locomotor activity of GluR-A−/− and GluR-A(R/R) mutant mice and their wild-type controls. The mice received either saline (10 ml/kg, i.p.) or different doses of MK-801, after which they were immediately transferred into locomotor cages for the determination of horizontal activity counts for 2 hr sessions. The barsindicate mean ± SEM for 11–20 animals in GluR-A−/− and control groups and for 10–13 animals in GluR-A(R/R) and their control groups. *p < 0.05 for the difference from the corresponding saline group; Dunnett's test. There were no significant differences between the mutants and their controls.