Table 1.
Data summary for the parameters measured in hippocampi of Tg2576 mice at different ages as compared with age-matched control animals
| Protein detected | Age (months) | ||
|---|---|---|---|
| 4 | 13 | ∼20 | |
| CA1 | |||
| ERK2 MAPK | 0.95 ± 0.06 | 1.10 ± 0.07 | 0.78 ± 0.06 |
| (ns) | (ns) | (0.017) | |
| Phospho-ERK2 MAPK | 0.85 ± 0.09 | 1.15 ± 0.06 | 0.73 ± 0.06 |
| (ns) | (0.03) | (0.001) | |
| CREB | 1.02 ± 0.11 | 0.93 ± 0.13 | 1.03 ± 0.14 |
| (ns) | (ns) | (ns) | |
| Phospho-CREB | 1.27 ± 0.16 | 1.50 ± 0.25 | 0.82 ± 0.07 |
| (ns) | (0.041) | (0.015) | |
| α7 nAChR | 1.15 ± 0.17 | 1.45 ± 0.33 | 19.17 ± 5.89 |
| (ns) | (ns) | (0.002) | |
| DG | |||
| ERK2 MAPK | 0.97 ± 0.09 | 1.06 ± 0.09 | 1.01 ± 0.08 |
| (ns) | (ns) | (ns) | |
| Phospho-ERK2 MAPK | 1.40 ± 0.23 | 1.56 ± 0.13 | 1.13 ± 0.10 |
| (0.05) | (0.001) | (ns) | |
| CREB | 1.17 ± 0.10 | 1.78 ± 0.35 | 1.35 ± 0.16 |
| (ns) | (0.025) | (0.03) | |
| Phospho-CREB | 1.64 ± 0.29 | 0.90 ± 0.17 | 1.19 ± 0.16 |
| (0.015) | (ns) | (ns) | |
| α7 nAChR | 1.57 ± 0.16 | 1.82 ± 0.40 | 10.00 ± 2.08 |
| (0.005) | (0.028) | (<0.001) | |
Relative densities are measured from immunoblots as described. Mean normalized densities are reported ± SEM. In parentheses below each mean value are Student's t test results. ns, Not significant.