Fig. 4.

GABA_A receptor [³H]muscimol binding and relative protein content for GABA_A receptor α1 and β2/3 subunits.A, B_max values for [³H]muscimol binding to the high-affinity binding site of the GABA_A receptor in the adult guinea pig (P61) cerebral cortical cell membrane protein. The data are presented as the mean ± SEM of eight offspring. Representative immunoblot bands and mean ± SEM (n = 8 offspring in each treatment group) data for GABA_A receptor α1 (B) and β2/3 (C) subunit proteins in adult guinea pig (P61) cerebral cortex. The data are expressed as relative amount of GABA_A receptor subunit protein normalized to β-actin protein. *p < 0.05 for the increase in each of [³H]muscimolB_max (A), and the relative amounts of protein for the GABA_A receptor α1 (B) and β2/3 (C) subunits in the ethanol treatment group compared with the isocaloric-sucrose/pair-fed and water treatment groups.