Fig. 1.

Selective accumulation of nuclear huntingtin aggregates in striatal neurons in HD-repeat knock-in mice. Low-magnification micrographs of brain sections from an R6/2 mouse at 12 weeks of age and a HD-repeat knock-in mouse at 24 months of age are shown. The sections were stained with EM48. Nuclear huntingtin aggregates are widely distributed in R6/2 mice, which express N-terminal mutant huntingtin. In the HD-repeat knock-in mouse brain, which expresses full-length mutant huntingtin, only the striatal neurons (Str) were immunoreactive with EM48.Ctx, Cortex; Hipp, hippocampus;Cereb, cerebellum. Scale bars, 25 μm.