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. 2001 Nov 1;21(21):8473–8481. doi: 10.1523/JNEUROSCI.21-21-08473.2001

Fig. 3.

Fig. 3.

Age dependence of neuropil aggregates in HD-repeat knock-in mice. A, EM48 immunostaining of the LGP in HD knock-in mice at 4, 8, 12, and 24 months of age. The density of neuropil aggregates is greater in older mice. Scale bar, 10 μm.B, Quantification of neuropil aggregate density in various brain regions from HD-repeat knock-in mice at different ages (7–24 months). Values are expressed as the mean ± SD and were obtained by counting aggregates in three to five images (8455 μm2/per image) for each brain region.Ctx, Cortex; STR, striatum.