Table 1.

Neuropil aggregates and early neuropathology

	Cortex	Striatum	LGP	MGP	SN
Neuropil degeneration in presymptomatic HD patients1-a	ND1-b	ND	Yes	ND	Yes
Neuropil aggregate density in HD knock-in mice	Very low	Low	High	Low	High
Axonal degeneration in HD knock-in mice	No	No	Yes	No	Yes

^F1-aAlbin et al., 1990, 1992.

^F1-bND, Not detected.