Fig. 3.

Dose-dependent rescue of spongiform encephalopathy in sod2 nullizygous mice. A shows the trigeminal motor nuclei (hematoxylin and eosin) (400× magnification) of a 3-week-old sod2 nullizygous mouse treated with EUK-8 at 1 mg/kg; prominent spongiform changes are seen that are consistent with those reported previously in MnTBAP-treated sod2 nullizygous mice (Melov et al., 1998). B shows the equivalent regions from a 3-week-oldsod2 nullizygous mouse treated with EUK-8 at 30 mg/kg, demonstrating the rescue of spongiform changes.