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. 2001 Nov 1;21(21):8348–8353. doi: 10.1523/JNEUROSCI.21-21-08348.2001

Fig. 4.

Fig. 4.

Increase in mitochondrial aconitase activity in the brains of sod2 nullizygous mice at 3 weeks of age.Open bars, MnTBAP-treated sod2−/− mice (n = 11); graybars, EUK-8-treated sod2−/− mice (n = 6); closed bars, EUK-8- or MnTBAP-treated sod2+/+ mice or untreatedsod2+/+ mice. BS, Brain stem;Str, striatum; Ctx, cortex;Cb, cerebellum. Mitochondrial aconitase activity in the brains of sod2 nullizygous mice treated with EUK-8 compared with mitochondria isolated from MnTBAP-treated mice at 3 weeks of age via nonparametric t tests reveals that EUK-8 treatment results in statistically significant increases in the level of mitochondrial aconitase activity (*p < 0.05; **p < 0.01). No statistically significant difference was observed in the activity of brain mitochondrial aconitase from sod2+/+ mice treated with either EUK-8 or MnTBAP compared with untreated controls; therefore, these mice were grouped together. Error bars represent the SEM.