Fig. 4.

Selective hippocampal cell loss progressed for weeks after TBI. This summary of the time course and regional distribution of selective cell loss in the hippocampus is based on Fluoro-Jade and cresyl violet staining 1 d (1 Day) to 27 weeks (24–27 W) after TBI, as indicated. Regions of visually discernable cell loss 2.5, 3.8, and 5.6 mm posterior to bregma are marked by filled diamonds. Gross cell loss in the CA3 progressed to temporal regions (i.e., posteriorly) and also from CA3a to CA3c over weeks after TBI. In the hilus, gross cell loss was detected in Fluoro-Jade-stained septal sections by 1 d, in cresyl violet-stained septal sections by 3 weeks, and in temporal hippocampus by 27 weeks after TBI.