Table 1.
TBI induced persistent hyperexcitability in the DG, revealed by disinhibition
| Group | In vitro treatment | Number of population spikes | pEPSP duration | n(rats) | ||
|---|---|---|---|---|---|---|
| Median (minimum, maximum) | Mean ± SE | |||||
| First shock | Second shock | First shock | Second shock | |||
| Normal control | 15 | |||||
| Normal ACSF | 1 (1, 2) | 1 (1, 2) | 14.0 ± 2.6 | 16.6 ± 3.9 | ||
| GABAA blocker | 1 (1, 2) | 1 (1, 2) | 18.0 ± 2.1 | 22.0 ± 4.7 | ||
| 2–3 weeks after TBI | 14 | |||||
| Normal ACSF | 1 (1, 2) | 1 (1, 3) | 19.0 ± 4.7 | 27.9 ± 7.2 | ||
| GABAAblocker | 3 (1, 5) | 4 (1, 8)* | 28.3 ± 2.1 | 41.4 ± 2.1 | ||
| 14–15 weeks after TBI | 8 | |||||
| Normal ACSF | 1 (1, 2) | 1 (1, 2) | 17.5 ± 3.2 | 26.6 ± 6.9 | ||
| GABAAblocker | 3 (1, 6) | 5 (1, 8)* | 30.9 ± 0.5 | 45.0 ± 0.61-160 | ||
*
Different from normal control during disinhibition;p < 0.01 in Dunn's test with two comparisons.
F1-160: Different from normal control during disinhibition;p < 0.05 in two-tailed t test after correction for four comparisons after Bonferroni's method (including the two comparisons with Dunn's test).