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Double-plotted wheel-running activity records of two representative profiles from three 5-HT antagonist treatment groups. All were pretreated with p-CPA. Theshaded horizontal bars represent the 3 hr microdialysis perfusion from ZT 6 to ZT 9. A, B, SCN 8-OH-DPAT perfusion in darkness; C, D, SCN 8-OH-DPAT plus intraperitoneal ritanserin injection in darkness;E, F, SCN 8-OH-DPAT plus DR4004 perfusion in darkness.
