Fig. 3.

Summary of thermal stimulus-evoked activity of lamina V neurons 10–20 and 70–80 min after MO. a, c, Stimulus–response functions to 41, 45, and 49°C (presented every 5 min for 80 min) are shown for +/+ (filled squares) and −/− (open circles) mice. Thedashed lines in a indicate the preinjury stimulus–response profile. b, d, The integrated average of all temperatures is illustrated. The horizontal dashed lines denote the mean pre-MO evoked activity in +/+ (filled bars) and −/− (open bars) mice. At 10–20 min after MO, there was a significant increase in total stimulus-evoked activity at all temperatures. However, by 70–80 min, there is a significant difference in stimulus-evoked activity between +/+ and −/− mice, and neurons in the −/− mice no longer encode stimulus intensity. *p < 0.05.