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. 2001 Jul 15;21(14):5017–5026. doi: 10.1523/JNEUROSCI.21-14-05017.2001

Fig. 1.

Fig. 1.

Determination of the commitment point for neuronal death by DNA damage and protection by CDK inhibitors. A, Determination of the commitment point for neuronal death by DNA damage. Cortical cultures were treated with camptothecin (campto; 10 μm) at 0 hr and removed at the indicated times; neuronal survival was determined at 24 hr after treatment. B, Determination of the commitment point for protection by CDK inhibition. The CDK inhibitor flavopiridol (1 μm) was added to cortical cultures treated with camptothecin at the indicated times; neuronal survival was determined at 24 hr after treatment. In each experiment the viability was assessed by nuclear counts. Eachpoint is the mean ± SEM of data from three cultures.