Fig. 1.

The breathing patterns of C3H and Tg8 mice are different. A (top tobottom), Global electromyogram of the diaphragm (Dia global EMG), integrated Dia global EMG (Dia int EMG), pneumotachographic recording, tidal volume (V_T), and airflow (dV/dt) in an anesthetized adult C3H mouse. Breathing parameters are shown: inspiratory duration (T_I), expiratory duration (T_E), total respiratory cycle duration (T_TOT), and VT.B, The histograms give the mean value (±SEM) ofT_I,T_E,T_TOT, andV_T for 19 C3H mice (white bars) and 17 Tg8 mice (black bars). Note that the mean T_I is shorter and the meanV_T smaller in Tg8 than in C3H mice (* indicates a statistically significant difference atp < 0.05).