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Dvl-1 increases sAPPα but not total APP expression or sAPPβ secretion. Transfection of dvl-1 had no effect on the total expression of APP as assessed by the N-terminal antibody 22C11 when used to probe cell lysates (A). Transfection of dvl-1 resulted in an increase in sAPP produced by α-secretase but not those products resulting from β-secretase processing, as demonstrated by Western blots of concentrated media using antibodies specific for each (B).
