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A, Western blots showed a time-dependent degradation of the BBB-associated protein ZO-1 after ischemic onset. Densitometric analysis demonstrated that ZO-1 degradation was significantly ameliorated in MMP-9 knock-out mice (KO). n = 5 animals per time point; *p < 0.05. B, Western blots showed no significant change in another BBB-associated protein, occludin.n = 5 animals per time point.
