Fig. 3.

Elimination of Kv2 channel function had minimal effect on activation kinetics of I_Kv.A, B, Time to half maximum (t_1/2) ofI_Kv recorded from either immature (A) or mature (B) neurons. At either stage in culture, overexpression of the dominant-negative subunit led to minimal if any difference in the averaget_1/2. C, D, Distribution oft_1/2 values in individual neurons also revealed little difference between control and +Mutantneurons at either immature (C) or mature (D) stages. The histograms present data obtained +0 mV, a voltage at which the average values showed a small, nonsignificant difference (A, B).