Table 2.

Suppression of Kv2, but not Kv1, channels prolongs the duration of the impulse

Property	Control (n = 24)	+ Kv1 Mutant (n = 12)	+ Kv2 Mutant(n = 32)
Amplitude (mV)	122  ± 3	122  ± 7	121  ± 2
Overshoot (mV)	43  ± 3	46  ± 7	42  ± 2
Rate of rise (V/sec)	174  ± 11	131  ± 15*	148  ± 7NS2
Rising duration (msec)	1.4  ± 0.1	1.2  ± 0.3	1.6  ± 0.1
Falling duration (msec)	1.0  ± 0.1	1.5  ± 0.3NS	3.9  ± 1.2**
Holding potential (mV)	−79  ± 1	−76  ± 3	−79  ± 1
Resting potential (mV)	−47  ± 2	−38  ± 3NS	−42  ± 1NS2

NS, Not significantly different from control.

NS2, Not significantly different from control or + Kv1 Mutant.

*p<0.02 versus control.

**p<0.005 versus control.