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. 2001 Mar 1;21(5):1787–1794. doi: 10.1523/JNEUROSCI.21-05-01787.2001

Fig. 5.

Fig. 5.

Effect of modafinil (90 mg/kg) on sleep states in wild-type (+/+) and DAT knock-out (−/−) mice. Data are the percentages of time (mean ± SEM in 2 hr bins) in NREM, REM, and wake in the 24 hr pretreatment and 24 hr posttreatment periods. Open circles, Vehicle (0.25% methylcellulose vehicle); filled circles, modafinil (90 mg/kg).Arrows indicate injection. Light–darkbars at the bottom of the panels indicate lighting schedule. Two-way repeated-measures ANOVA indicated postinjection treatment × time interactions for wake, NREM, and REM sleep in both DAT +/+ (p < 0.001 for wake, NREM, and REM) and DAT −/− (p = 0.007, 0.004, and 0.007, respectively) mice, but increased wake after modafinil administration was only observed in DAT +/+ mice. Sample sizes (+/+, −/−): vehicle (9, 8); modafinil (10, 9).