Fig. 9.

α-conotoxin MII inhibits the MLA-sensitive component of ACh-gated currents. A, In an SNc DA neuron, α-conotoxin MII (10 nm) inhibits the ACh-gated current. In the panel labeled superimposition, the MLA trace is in gray. B, In the same neuron, increased concentration of α-conotoxin MII (100 nm) does not result in greater inhibition (note change in scale); addition of MLA (1 nm) to the α-conotoxin MII (100 nm) also has no effect (middle). In thesuperimposition panel, the α-conotoxin MII (100 nm) and MLA traces are in gray. α-Cntx MII, α-Conotoxin MII.