Fig. 4.

GST-Pi⁺ mature oligodendrocytes in the corpus callosum of wild-type andIL-1β^−/− mice during demyelination and remyelination. GST-Pi⁺ mature oligodendrocytes in the corpus callosum of untreated wild-type (A) and IL-1β^−/− (B) mice at 0 weeks. Mature oligodendrocyte recovery of wild-type (C) and IL-1β^−/−(D) mice at 5 weeks of treatment. Recovery of GST-Pi⁺ cells in the corpus callosum of wild-type (E) and IL-1β^−/−(F) mice at 10 weeks. G, The mean and SEM bars representing the number of GST-Pi⁺cells per square millimeter are plotted for the triplicate set of samples. Scale bar, 50 μm. CC, Corpus callosum. Thewhite dashed line separates the corpus callosum and fornix. *p < 0.005; **p < 0.0005.