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Fluoro-jade labeling demonstrates caspase 3 requirement for neuronal cell death in the Rb-deficient peripheral nervous system. Shown are ΔC-APP (A, C) and Fluoro-jade (B, D) double labeling of degenerating DRG neurons in Rb−/− (A, B) and Rb/caspase 3 double knock-out embryos (C, D). Arrows indicate DRGs. Scale bar, 260 μm.
