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Rb−/−:caspase 3−/− double mutants exhibit normal levels of Trk A expression. Trk A is highly expressed in wild-type (A) and caspase 3−/− (B) DRGs by E13.5. This staining is dramatically reduced in Rb-deficient DRG neurons (C); however, Trk A staining is restored to wild-type levels when caspase 3 is also absent (Rb/Casp3−/−) (D). Scale bar, 150 μm.
