Fig. 1.
A, Concentration-dependent increase of 5-HT in dialysates from medial prefrontal cortex evoked by the local application of 1, 10, and 100 μm of the partial 5-HT2A/2C receptor agonist DOI (filled circles; n = 5). The bar graph in theinset shows the average increase in 5-HT obtained from the last four (stabilized) fractions at each DOI concentration (+p < 0.05 vs baseline).B, Effect of the continuous application of 100 μm DOI (filled squares;n = 7). Control rats (n = 6) received artificial CSF throughout the experiment. Bars show the period of drug application. +p < 0.05 versus baseline; Duncan test post-ANOVA.