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The systemic administration of DOI (1 mg/kg, s.c.) markedly reduced the 5-HT output in mPFC of chloral hydrate-anesthetized rats (n = 4). The selective 5-HT2A receptor antagonist M100907 (0.5 mg/kg, s.c.) fully reversed the effect of DOI. Arrows mark injections.+p < 0.05 versus baseline; *p < 0.05 versus DOI alone; Duncan test post-ANOVA.
