Table 1.

Areas activated during exacerbation of pain by increases in anxiety or temperature

Brain region (Brodmann area)	Side	Talairach coordinates			Zvalue		Z threshold
		X	Y	Z	Mean	Max.	p= 0.05, cor.
Pain modulation by anxiety
Entorhinal cortex (28)	L	−22	−17	−26	3.57	4.61	3.44
Mid-insula/parainsular cortex (52)*	R	44	−10	3	3.76	4.98	3.41
	L	−53	−11	5	3.90	5.96	3.41
Perigenual cingulate (24/32)*	L/R	1	37	9	3.88	5.96	3.41
Pain modulation by temperature
Hippocampus	L	−18	−24	−13	3.46	4.30	3.34
	R	21	−21	−14	3.78	4.82	3.34
Orbitofrontal cortex (11)	L/R	−1	58	−13	3.46	4.33	3.34
SI/MI	L	−52	−13	41	3.48	4.26	3.34
	R	42	−14	48	3.77	5.81	3.34
Posterior insula	L	−39	−19	15	3.56	4.39	3.34
	R	37	−19	14	3.60	4.63	3.34
Thalamus	L/R	−1	−9	2	3.75	4.90	3.34
Midcingulate (24′/32′)	L/R	1	−11	46	4.02	6.20	3.34

p = 0.001; Z = 3.09.

^*Area shows activity significantly correlated with the entorhinal FMRI signal during LT/HA and LT/LA (p< 0.001).