Fig. 7.

Developmental profile of epileptiform activity.A, Synaptic activity in CA3 pyramidal cells in the presence of bicuculline (10 μm). At midgestation (E85), no seizure activity is observed; at E105, epileptiform events emerge and progress in occurrence and severity during the second half of gestation. Whole-cell recordings at holding potential of −60 mV. At E85 and E105, the responses were evoked by electrical stimulation of the slice (marked by arrows); at E109 and E154, spontaneous interictal-like events are shown. B, Plot summarizing the occurrence of the bicuculline-induced seizure activity in the fetal macaque hippocampal slices (number of cells). Note that all neurons express epileptiform activities from E134 onward.