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. 2001 Sep 1;21(17):6502–6511. doi: 10.1523/JNEUROSCI.21-17-06502.2001

Fig. 1.

Fig. 1.

Application of serotonin causes a reduction of GABAA receptor currents in PFC pyramidal neurons.A, Time course of peak current evoked by GABA (100 μm) in the absence (control) or presence of serotonin (20 μm). The starting point for continuous application of serotonin is marked by the arrow. Application of serotonin caused an inhibition of GABAA receptor currents, whereas repeated application of GABA alone evoked a current that was stable during the whole-cell recording. B, Box plot summary of the percentage of reduction of peak GABAAcurrents produced by serotonin in a sample of 21 PFC pyramidal neurons.C, Plot of peak GABAA current as a function of time and ligand application. In the presence of the nonselective 5-HT receptor antagonist methysergide (meth; 10 μm), serotonin had little effect on GABAAcurrents; washing off the antagonist led to recovery of the serotonin inhibition (wash). The inset is a box plot summary showing the percentage of serotonin effect blocked by methysergide (n = 8). D, Representative current traces taken from the records used to constructC (at time points denoted by *).