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. 2001 Sep 1;21(17):6502–6511. doi: 10.1523/JNEUROSCI.21-17-06502.2001

Fig. 3.

Fig. 3.

Serotonergic modulation of GABAAcurrents is mediated by 5-HT2 receptors. A, Plot of peak GABAA current as a function of time and agonist application. The 5-HT2A/C agonist DOI (10 μm) caused an inhibition of GABAA currents.B, Representative current traces taken from the records used to construct A (at time points denoted by *).C, Plot of peak GABAA current as a function of time and ligand application. The 5-HT2 receptor antagonist risperidone (ris; 10 μm) blocked the effect of DOI on GABAA currents.D, Box plot summary of the percentage of reduction of peak GABAA currents produced by DOI or 5-HT in the absence and presence of different antagonists. The 5-HT2-class antagonist risperidone (ris; 10 μm) and ketanserin (ket; 20 μm) blocked the effect of DOI and 5-HT, whereas the 5-HT1-class antagonist cyanopindolol (cya; 20 μm) was ineffective.