Table 1.
Hz | 0 | 1 | 1 | 0.1 | 0.3 | 0.5 | 1 | 3 | 10 | 1 | 3 | 10 | 10 | 1 | 10 | ||||
AP | 0 | 5 | 15 | 45 | 45 | 45 | 45 | 45 | 45 | 150 | 150 | 150 | 450 | 600 | 6000 | ||||
sec | 0 | 5 | 15 | 450 | 150 | 90 | 45 | 15 | 4.5 | 150 | 50 | 15 | 45 | 600 | 600 | ||||
n | 32 | 9 | 15 | 13 | 9 | 9 | 21 | 10 | 15 | 3 | 3 | 15 | 15 | 6 | 6 | ||||
% | 100 | 106 | 147 | 93 | 114 | 131 | 127 | 126 | 128 | 142 | 128 | 164 | 124 | 116 | 104 | ||||
AP | Hz | sec | n | % | |||||||||||||||
0 | 0 | 0 | 32 | 100 | x | ||||||||||||||
5 | 1 | 5 | 9 | 106 | NS | x | |||||||||||||
15 | 1 | 15 | 15 | 147 | * | * | x | ||||||||||||
45 | 0.1 | 450 | 13 | 93 | NS | NS | * | x | |||||||||||
45 | 0.3 | 150 | 9 | 114 | NS | NS | * | NS | x | ||||||||||
45 | 0.5 | 90 | 9 | 131 | * | NS | NS | * | NS | x | |||||||||
45 | 1 | 45 | 21 | 127 | * | NS | NS | * | NS | NS | x | ||||||||
45 | 3 | 15 | 10 | 126 | * | NS | NS | * | NS | NS | NS | x | |||||||
45 | 10 | 4.5 | 15 | 128 | * | NS | NS | * | NS | NS | NS | NS | x | ||||||
150 | 1 | 150 | 3 | 142 | * | NS | NS | * | NS | NS | NS | NS | NS | x | |||||
150 | 3 | 50 | 3 | 128 | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | x | ||||
150 | 10 | 15 | 15 | 164 | * | * | NS | * | * | * | * | * | * | NS | NS | x | |||
450 | 10 | 45 | 15 | 124 | * | NS | NS | * | NS | NS | NS | NS | NS | NS | NS | * | x | ||
600 | 1 | 600 | 6 | 116 | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | * | NS | x | |
6000 | 10 | 600 | 6 | 104 | NS | NS | * | NS | NS | NS | NS | NS | NS | NS | NS | * | NS | NS | x |
A subset of these data are plotted against stimulus time in Figure 5A and action potential number in Figure5B; p < 0.0001 by one-way ANOVA;n = 178. %, Autonomous CaMKII activity relative to unstimulated control; Hz, stimulus frequency (action potentials/sec); AP, number of action potentials in stimulus; sec, stimulus duration in seconds; n number of samples (cultures);
p < 0.05, pairwise comparison; NS,p > 0.05, pairwise comparison.