Table 1.

Electrophysiological properties of intracellularly recorded striatal neurons in control and 6-hydroxydopamine-lesioned rats

	Control	6-OHDA
Number of silent neurons	131-a	4
Number of neurons firing spontaneously	14	27
Action potential amplitude (mV)1-b	50.3  ± 1.8	50.9  ± 0.9
Action potential duration (msec)1-c	0.85  ± 0.03	0.81  ± 0.03
Threshold (spontaneous firing) (mV)1-d	−54.8  ± 1.0	−54.5  ± 0.8
Input resistance (MΩ)1-e	53.0  ± 3.3	51.9  ± 4.7
Silent neurons
Voltage in the down state (mV)	−87.4  ± 3.5	−87.4  ± 4.3
Voltage in the up state (mV)	−77.5  ± 3.8	−76.8  ± 4.7
Spontaneously active neurons
Voltage in the down state (mV)	−82.4  ± 3.1	−73.3  ± 1.81-f
Voltage in the up state (mV)	−69.7  ± 2.1	−63.1  ± 1.31-g
Duration of the recordings (minutes, mean ± SEM, and range)1-h	49  ± 8 (11–179)	51  ± 9 (11–208)

Data are mean ± SEM. Spike measures were taken from spontaneously active neurons.

^F1-ap = 0.004 Fisher exact probability test.

^F1-bMeasured from threshold.

^F1-cMeasured at half maximal amplitude.

^F1-dDefined as the membrane potential at which the rate of voltage change exceeded 4 V/sec (Wickens and Wilson, 1998).

^F1-eMeasured by applying depolarizing current pulses during the down state.

^F1-fp = 0.012, two-tailed Student's t test.

^F1-gp = 0.046, two-tailed Student's t test.

^F1-hIncludes the time spent in the application of Neurobiotin.