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. 2001 Aug 15;21(16):5864–5870. doi: 10.1523/JNEUROSCI.21-16-05864.2001

Fig. 1.

Fig. 1.

A, C-terminal proteolytic processing of pre-POMC (pPOMC). A schematic representation of the β-LPH–β-endorphin processing pathway in the rodent hypothalamus. B, A schematic representation of ppOFQ/N processing in the rodent hypothalamus. Predicted and potential cleavages by PC1and PC2 based on pituitary POMC processing are indicated. The processing patterns shown are thought to occur in mice expressing WT PC2. K, Lysine;R, arginine. Asterisks denote potential paired basic cleavages in OFQ/N. Arrows denote PC cleavage sites.