Fig. 2.

DHPG-induced inward current and depolarization in CA1 hippocampal neurons most likely are mediated by decreasing a leak potassium conductance. A, The mGluR1-mediated inward current observed in CA1 pyramidal neurons is associated with a decrease in membrane conductance (top vs bottomtrace). B, This decrease in membrane conductance is evident in the whole-cell current–voltage relation. Theinset shows the subtraction of the currents that reveals a linear I–V relationship, which is inward at normal resting potentials and reverses near the predicted potassium equilibrium potential. Axis titles in B apply in theinset. The figure is representative of the results that were observed in three of four cells.