Fig. 3.
The DHPG-induced suppression ofIAHP in CA1 pyramidal neurons is mediated by mGluR5. A, Time course from a single experiment showing the suppression of IAHP induced by the application of 30 μm DHPG. Lettersindicate the time of the corresponding traces that are shown at thetop. B, The 10 min preapplication of 10 μm MPEP antagonizes the DHPG-induced suppression ofIAHP. C, Bar graph summarizing mean data showing that the DHPG-induced suppression ofIAHP is blocked selectively by MPEP but is not altered by preincubation with the mGluR1-selective antagonist LY367385 (100 μm). The number of cells that have been tested is in parentheses; values are the means ± SEM of the data, expressed as a percentage of controlIAHP peak values. *p < 0.05 versus control; Student's t test.