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. 2001 Aug 15;21(16):6348–6361. doi: 10.1523/JNEUROSCI.21-16-06348.2001

Fig. 9.

Fig. 9.

5-HT immunoreactivity is present in the ENS of both SERT +/+ and SERT −/− mice. 5-HT immunoreactivity was demonstrated in laminar preparations of the bowel wall containing either the myenteric or submucosal plexus without preloading the tissue with an exogenous 5-HT-immunoreactive molecule or otherwise amplifying the endogenous 5-HT content of the bowel. Tissue was kept on ice during dissection and fixed immediately thereafter to minimize the potential for postmortem 5-HT uptake. Preparations from SERT +/+ mice are illustrated in A, C, and E. Preparations from SERT −/− mice are illustrated in B, D, and F.A, B, Stomach. C, Colon.D, Ileum. E, F, Colon. The locations of nerve cell bodies are indicated by thearrows [A, B(inset), C]. The locations of neurites in the tertiary plexus are indicated by arrowheads(B–D).