Fig. 6.

Effect of AMPH (10 μm) on DA overflow amplitudes in striatal slices of D2 receptor KO mice (D2−/−) recorded with CV. a, Normalized maximal signal amplitudes (average ± SEM) are plotted for 29 min of AMPH superfusion of slices from D2 KO mice (black circles; n = 5) and slices from wild types (WT) with (white squares) and without (white circles) 2 μm sulpiride (data from Figs. 4, 5). b, Example of CV recordings from a D2 KO mouse before and after 25 min of AMPH superfusion (white circles) with simulation of the data (thin lines).