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. 2001 Aug 15;21(16):5973–5983. doi: 10.1523/JNEUROSCI.21-16-05973.2001

Fig. 2.

Fig. 2.

Effects of an ibotenic acid lesion in the entorhinal cortex on Kv1 α and β subunit immunoreactivity in the hippocampus. These photomicrographs show the pattern of immunoreactivity for Kv1.1, Kv1.4, Kv1.2, and Kvβ2 in the hippocampus of the unoperated control hemisphere (A, C, E, G) and in the operated hemisphere (B, D, F, H) of an animal that sustained a large unilateral ibotenic acid lesion in the entorhinal cortex. In the control hemisphere, there is a distinct band of immunoreactivity for all four subunits in the middle third of the molecular layer of the dentate gyrus (arrowheads). The location of this band corresponds to the termination zone of projections from the medial entorhinal cortex to the dentate gyrus. After the ibotenic acid lesion, the band of immunoreactivity for Kv1.1 and Kv1.4 in the ipsilateral dentate gyrus is eliminated (B, D, arrowheads), and the band of immunoreactivity for Kv1.2 and Kvβ2 is greatly diminished in intensity (F, H, arrowheads). DG, Dentate gyrus;Sub, subiculum.