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. 2001 Aug 15;21(16):6362–6369. doi: 10.1523/JNEUROSCI.21-16-06362.2001

Fig. 9.

Fig. 9.

Effect of local administration of 10 μm AMPA on glutamate efflux from the VTA of amphetamine- and saline-pretreated rats tested 3 d after the last injection. AMPA was administered for 30 min during sample 5. One-way ANOVA with time as the repeated measure indicated a significant change in glutamate efflux over time within the amphetamine group (F(7,49) = 3.32; p< 0.01) but not the saline group (F(7,42) = 1.72; p= 0.13). Within the amphetamine group, contrast analysis revealed a statistically significant difference between the weighted means of the baseline samples (1–4) and the post-AMPA samples (5–8) (p < 0.001). Contrast analysis comparing the weighted mean of the baseline samples with individual post-AMPA samples (5–8) indicated significantly higher efflux of glutamate for samples5–8 (**p < 0.01; *p < 0.05). Basal glutamate levels were 18.8 ± 2.7 pg/μl in the saline group (n = 7) and 18.0 ± 2.3 pg/μl in the amphetamine group (n = 8) and did not differ significantly between groups.