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. 2001 Aug 15;21(16):6026–6035. doi: 10.1523/JNEUROSCI.21-16-06026.2001

Fig. 5.

Fig. 5.

Tau-rich aggregates in the axons of the peripheral white matter of spinal cord contain straight tau filaments.A, NFs are evenly distributed in a spinal cord myelinated axon of a WT mouse. B, C, Few NFs (arrowheads) and more microtubules (short arrows) are seen in the NFL−/− (B) and T44;NFL−/− (C) mice. D–F, A mass of loosely packed disorganized filaments (large arrow) in a spinal cord unmyelinated axon of a 12-month-old T44;NFL−/− mouse. D–F show the same aggregate at different magnification. G–I, A mass of tightly packed disorganized filaments in a myelinated axon of spinal cord in a 12-month-old T44;NFL−/− mouse. G–I show the same aggregate at increased magnification. J–L, Preembedding immuno-EM labeled the aggregates with antibody 17026 in a 12-month-old T44;NFL−/− mouse. J–L show the same aggregate at different magnifications. Note that silver enhancement was performed for 17026 staining. Scale bars: A–C, 500 nm;D, G, J, 10 μm;E, H, K, 500 nm;F, I, L, 100 nm.