Fig. 3.
Effects of the α4(V) NTD and collagen domain of type V collagen on Schwann cell migration. A, Diagram illustrating the proposed domain structure of collagen type VSC. B, Rat embryo dorsal root ganglia were plated on dishes coated with the indicated proteins and cultured for 4 d in serum-free medium with heregulin. Schwann cell (SC) migration was quantitated as described in Materials and Methods. Data shown are mean ± SD of measurements made on four ganglia. *Values that are significantly different from control values. C, Schwann cell migration from dorsal root ganglion explants was visualized by phase contrast microscopy.Fn, Fibronectin; IV, collagen type IV;pep V, pepsinized collagen type V; con, control dishes (uncoated plastic).