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. Author manuscript; available in PMC: 2019 Sep 26.
Published in final edited form as: Mol Pharm. 2019 Jun 19;16(7):3065–3071. doi: 10.1021/acs.molpharmaceut.9b00293

Figure 3.

Figure 3.

The antibacterial activity of PTM and PTM-2t in MRSA induced skin infection in mouse. (A) Therapeutic efficacy of PTM and PTM-2t in a mouse skin infection model, Mupirocin was used as the positive control. The infected mice were treated twice a day for 7 days. (B) The total bacterial loads in the skin lesions were determined. Statistical analysis was calculated by the Mann-Whitney test. P values of (*P<0.05) (**P<0.01) were considered as significant. P values (**P<0.01) were: vehicle versus 2% mupirocin, 0.0022; vehicle versus 2% PTM, 0.0043; vehicle versus 2% PTM-2t, 0.0022. (C) Wounds of BALB/c mice with treated and untreated with compounds at day 4, day 7 and day 9. (D) HE staining histological appearance of S. aureus-infected skin lesion on day 10. Biopsy specimens were taken immediately after the termination of the experiment, fixed in formalin, and embedded in paraffin. The biopsy specimens were stained with hematoxylin and eosin. Each point represents data from a single mouse. Mean values are presented, n=6. Abbreviations: D: Dermis; F: Fat layer; I: Inflammatory cells.