Figure 4.

Therapeutic efficacy of PTM-2t on MRSA infected mice. Vancomycin or saline were used as controls. At 1 h and 5 h post-infection, mice were treated with PTM at 10 mg/kg, PTM-2t at dose of 50 mg/kg and 10 mg/kg. The survival (A) and weights (B) of the infected mice were tracked for 14 days. (C) and (D) Quantitative comparison of blood and kidney bacterial counts of mice treated with vancomycin versus those of mice treated with PTM-2t at 14 days after administration. Each point represents data from a single mouse. Mean values are presented, n=5.