Table 1.

In vitro metabolic stability in mouse liver microsome of PTM and PTM-inspired thioether-analogues.

Entry	R	T1/2 (min)	Intrinsic Clearance (μL/min/mg)	Entry	R	T1/2 (min)	Intrinsic Clearance (μL/min/mg)
Sunitinib	-	13.1	53	2j	3-CF3C6H4	3.2	217
PTM	-	13.6	51	2k	2-CF3C6H4	5.7	122
2a	Ph	1.4	495	2l	4-NO2C6H4	1.5	462
2b	4-ClC6H4	1.6	433	2m	3,5-diFC6H4	1.6	433
2c	4-MeOC6H4	1.3	533	2n	3,5-diCF3C6H4	7.4	94
2d	4-MeC6H4	1.4	495	2o	-thiophene	1.6	433
2e	4-FC6H4	2.8	248	2p	-naphthyl	1.7	408
2f	3-FC6H4	1.6	433	2q	-CH3	9.5	73
2g	2-FC6H4	1.8	385	2r	4-FBn	1.4	495
2h	4-BrC6H4	1.5	462	2s	4-CH3C6H4	10.4	67
2i	4-CF3C6H4	1.6	433	2t	-CH2CH3	15.0	46