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. Author manuscript; available in PMC: 2019 Sep 26.
Published in final edited form as: Chem Rev. 2018 Jul 27;118(16):7409–7531. doi: 10.1021/acs.chemrev.7b00678

Figure 32.

Figure 32.

Proposed mechanisms of membrane permeabilization by detergents that flip flop. Integration of detergent monomers perturbs membrane integrity while stochastic local enrichment of detergents leads to formation of pores.