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. Author manuscript; available in PMC: 2019 Sep 26.
Published in final edited form as: Chem Rev. 2018 Jul 27;118(16):7409–7531. doi: 10.1021/acs.chemrev.7b00678

Figure 9.

Figure 9.

Chemical approaches for generating disruptions in lipid bilayers. (A) Chemical breakdown within a local region (red circle) can lead to disintegration of membrane integrity via breaking of bonds or distortion caused by unsaturation of lipid tails. (B) Pore-forming agents can interact with a membrane to assemble an oligomeric pore. (C) Perturbing surfactants (such as detergents) can embed into the bilayer and induce curvatures that distort the membrane and lead to loss of bilayer structure and pore formation.