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. 2019 Sep 9;129(10):4332–4349. doi: 10.1172/JCI121955

Figure 10. Nuclear YAP suppresses DLL4 expression in a TEAD-independent manner.

Figure 10

(A and B) TEAD1–4 siRNAs had no significant effect on mRNA (A) or protein (B) expression of DLL4. (C and D) Overexpression of YAP WT and 5SA and S94A mutants reduced mRNA (C) and protein (D) expression of DLL4 in sparse HUVECs. (E and F) Overexpression of the YAP 5SA mutant reduced mRNA (E) and protein (F) expression of DLL4 in overconfluent HUVECs. Data are mean ± SEM of triplicates. ***P < 0.001, 1-way ANOVA followed by Dunnett’s multiple-comparisons test. Unprocessed original scans of Western blots are shown in Supplemental Figure 14.