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. 2019 Sep 9;129(10):4365–4376. doi: 10.1172/JCI126809

Figure 3. Iron-regulating protein levels change prior to iron accumulation.

Figure 3

(A) Marmoset EAE lesions, categorized by age, and histopathology of iron and iron regulators, including transferrin receptor (TfR), ferroportin (FpN), hepcidin (HpC), and divalent metal transporter 1 (DMT1). Staining of serial sections from representative lesions shows that the expression level of all of these proteins increased before the accumulation of iron (>6 weeks). (B–D) Quantification of TfR, FpN, and HpC expression level, with standard error of the mean. Dots represent individual lesions. Counterstain: hematoxylin. Scale bars: 100 μm and are constant within each column of the figure (except for the positive control). Positive controls: marmoset liver for iron, FpN, and HpC; marmoset kidney for TfR and DMT1. Lesions selected from marmosets 6, 7, 8, and 9. **P < 0.01; ***P < 0.001 (ANOVA multiple comparisons test).